Resources
Drug Toxicity and
Adverse Drug Reactions
Hirata K, Takagi H,
Yamamoto M, Matsumoto T, Nishiya T, Mori K, Shimizu S, Masumoto H,
Okutani Y. Ticlopidine-induced hepatotoxicity is associated with
specific human leukocyte antigen genomic subtypes in Japanese
patients: a preliminary case-control study. Pharmacogenomics J.
2008 Feb;8(1):29-33. Epub 2007 Mar 6
PMID:
17339877
Ingelman-Sundberg M. Pharmacogenomic
biomarkers for prediction of severe adverse drug reactions. N Engl
J Med. 2008 Feb 7;358(6):637-9.
PMID:
18256400
Mallal S, Phillips E, Carosi G,
Molina JM, Workman C, Tomazic J, Jagel-Guedes E, Rugina S, Kozyrev
O, Cid JF, Hay P, Nolan D, Hughes S, Hughes A, Ryan S, Fitch N,
Thorborn D, Benbow A; PREDICT-1 Study Team. HLA-B*5701 screening
for hypersensitivity to abacavir. N
Engl J Med. 2008 Feb 7;358(6):568-79.
PMID:
18256392
SEARCH Collaborative Group, Link E,
Parish S, Armitage J, Bowman L, Heath S, Matsuda F, Gut I, Lathrop
M, Collins R. SLCO1B1 variants and statin-induced myopathy--a
genomewide study. N Engl J Med. 2008 Aug 21;359(8):789-99. Epub
2008 Jul 2
PMID:
18650507
Simon T, Verstuyft C, Mary-Krause M,
Quteineh L, Drouet E, Meneveau N, Steg PG, Ferrieres J, Danchin N,
Becquemont L; French Registry of Acute ST-Elevation and
Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators.
Genetic determinants of response to clopidogrel and cardiovascular
events. N Engl J Med. 2009 Jan 22;360(4):363-75. Epub 2008 Dec
22.
PMID:
19106083
Drug
Response
Ingelman-Sundberg
M, Sim SC, Gomez A, Rodriguez-Antona C. Influence of cytochrome
P450 polymorphisms on drug therapies: pharmacogenetic,
pharmacoepigenetic and clinical aspects. Pharmacol Ther. 2007
Dec;116(3):496-526. Epub 2007 Oct 9.
PMID:
18001838
Mega JL, Close SL, Wiviott SD, Shen
L, Hockett RD, Brandt JT, Walker JR, Antman EM, Macias W, Braunwald
E, Sabatine MS. Cytochrome p-450 polymorphisms and response to
clopidogrel. N Engl J Med. 2009 Jan 22;360(4):354-62. Epub 2008 Dec
22
PMID:
19106084
Drug
Transporter
Uhr M, Tontsch A,
Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M,
Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht
M, Pütz B, Binder EB, Müller-Myhsok B, Holsboer F. Polymorphisms in
the drug transporter gene ABCB1 predict antidepressant treatment
response in depression. Neuron. 2008 Jan 24;57(2):203-9
PMID:
18215618